Cyclic adenosine monophosphate (cAMP) and cAMP‐dependent protein kinase A (PKA) are evolutionary conserved molecules with a well‐established position in the complex network of signal transduction pathways. cAMP/PKA‐mediated signaling pathways are implicated in many biological processes that cooperate in organ development including the motility, survival, proliferation and differentiation of epithelial cells. Cell surface polarity, here defined as the anisotropic organisation of cellular membranes, is a critical parameter for most of these processes. Changes in the activity of cAMP/PKA elicit a variety of (...) effects on intracellular membrane dynamics, including membrane sorting and trafficking. One of the most intriguing aspects of cAMP/PKA signaling is its evolutionary conserved abundance on the one hand and its precise spatial–temporal actions on the other. Here, we review recent developments with regard to the role of cAMP/PKA in the regulation of intracellular membrane trafficking in relation to the dynamics of epithelial surface domains. BioEssays 30:146–155, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

This paper presents a new puzzle for limited aggregation. Unlike other recent puzzles, this one arises independently of the issue of rational aversion to risk. Some possible responses are laid out and explored.

Celem artykułu jest przedstawienie wybranych wątków związanych ze sprawowaniem przez Mikołaja Zebrzydowskiego urzędu starosty krakowskiego (1585–1620). Autor skoncentrował się na trzech kwestiach: objęciu starostwa, zaangażowaniu Zebrzydowskiego w sprawowanie wymiaru sprawiedliwości oraz wpływie rokoszu sandomierskiego (1606–1608) na działalność grodu krakowskiego. Główną podstawę źródłową tekstu stanowią krakowskie akta grodzkie, przechowywane w Archiwum Narodowym w Krakowie. Będąc studium przypadku, artykuł bada problem z perspektywy historycznoprawnej, krytycznie analizuje źródła oraz korzysta z metod statystycznych i porównawczych. Dzięki ich wykorzystaniu udało się odtworzyć przebieg czynności, które (...) doprowadziły do objęcia starostwa przez Zebrzydowskiego w 1585 r. Z zestawienia działalności Zebrzydowskiego z Janem Zamoyskim i Gabrielem Tarnowskim wynika, że jego zaangażowanie w sprawowanie wymiaru sprawiedliwości nie było duże, chociaż większe niż poprzednika i następcy. Limitując roki, Zebrzydowski chętnie powoływał się na sprawy prywatne, ale jego następca czynił to jeszcze częściej. Duży wpływ na funkcjonowanie starostwa miał rokosz sandomierski. Sąd nie działał przez ponad trzy i pół roku, urząd przez ponad 17 miesięcy, a kancelaria grodzka przez niecały rok. W sporze o położoną na Wawelu kamienicę starościńską, który stanowi symbol konfliktu Zebrzydowskiego z Zygmuntem III, rację należy przyznać królowi, pełnoprawnemu właścicielowi budynku, chociaż jego postępowanie w tej sprawie zaostrzało napięcie. (shrink)

Ex-ante deontology is an attempt to combine deontological constraints on doing or intending harm with the idea that one should act in everyone’s interest if possible. I argue that ex-ante deontology has serious problems in cases where multiple decisions are to be made over time. I then argue that these problems force us to choose between commonsense deontological morality and a more consequentialist morality. I suggest that we should choose the latter.

This paper examines a recent argument in favour of strong precautionary action—possibly including working to hasten human extinction—on the basis of a decision-theoretic view that accommodates the risk-attitudes of all affected while giving more weight to the more risk-averse attitudes. First, we dispute the need to take into account other people’s attitudes towards risk at all. Second we argue that a version of the non-identity problem undermines the case for doing so in the context of future people. Lastly, we suggest (...) that we should not work to hasten human extinction, even if significant risk aversion is warranted. (shrink)

The article explores the concept of infodemics during the COVID-19 pandemic, focusing on the propagation of false or inaccurate information proliferating worldwide throughout the SARS-CoV-2 health crisis. We provide an overview of disinformation, misinformation and malinformation and discuss the notion of “fake news”, and highlight the threats these phenomena bear for health policies and national and international security. We discuss the mis-/disinformation as a significant challenge to the public health, intelligence, and policymaking communities and highlight the necessity to design measures (...) enabling the prevention, interdiction, and mitigation of such threats. We then present an overview of selected opportunities for applying technology to study and combat disinformation, outlining several approaches currently being used to understand, describe, and model the phenomena of misinformation and disinformation. We focus specifically on complex networks, machine learning, data- and text-mining methods in misinformation detection, sentiment analysis, and agent-based models of misinformation spreading and the detection of misinformation sources in the network. We conclude with the set of recommendations supporting the World Health Organization’s initiative on infodemiology. We support the implementation of integrated preventive procedures and internationalization of infodemic management. We also endorse the application of the cross-disciplinary methodology of Crime Science discipline, supplemented by Big Data analysis and related information technologies to prevent, disrupt, and detect mis- and disinformation efficiently. (shrink)

The essay attends to a paradox found in some crucial poetic efforts by Wallace Stevens and John Ashbery. In some of their most important poetic works Stevens and Ashbery take on the task of positioning the poem toward the plurality of reality, the plurality that is concentrated in the phenomenon of change. As they do so, they invariably encounter a tension within the poem itself: as the poem merges with the flow of changes in the external world-the physical changes in (...) time and space-it also calls up permanent forms of imaginative purposive capability of attending to change, envisioning it, or, indeed, of installing it. These forms must be more permanent than it is postulated by some theories of the poetics of transitiveness, which are polemically discussed in the text. The tension between the element of change and permanence is what allows the poems of Stevens and Ashbery-each poet finding his own aesthetic and epistemic strategy-to put the poem forward not as an external “representation” of change, but as the very source of the abundant possibilities of producing world descriptions in which the notion of change may be meaningful. Such positioning of the poem is what I am calling “the poetics of plenitude.” This poetic strategy makes the poem an aesthetic counterpart to the epistemic action of developing an inquiry, and I am building a definition of this term by reference to the classical pragmatist theory of inquiry. This move is related to my treating Stevens and Ashbery as the poets belonging to the Emersonian-pragmatist intellectual and aesthetic tradition. The paradoxes of change and permanence discussed in the text are treated as inherent in this tradition. (shrink)

When considered in relation to remarks in Contingency, Irony, and Solidarity, Rortian irony becomes a target of criticisms that see it as marred by the conflict between skeptical distance and commitment. But such critique ignores the fact that Rortian irony belongs to a broader literary intuition. In this article I trace Rorty’s concept of irony to the structural properties of a specific group of literary texts. These texts bring together diverse materials the affinity between which is precisely what is at (...) stake in the interpretive game these texts put in motion: the formal, cognitive, and aesthetic coherence of these texts is a potentiality to be realized by readers. I treat the interpretive activity these texts depend on as equivalent to the practices by which inhabitants of democracies reexamine and recompose the materials of their networks of beliefs. Since such practices require a combination of ironic distance to the examined materials with a commitment to the interpretive process itself, they validate a Rortian model of irony. (shrink)

Personites are like continuant people but shorter-lived. Johnston argues that personites do not exist since otherwise personites would have the same moral status as persons, which is untenable. I argue that Johnston’s arguments fail. To do that I propose an alternative way to understand intrinsicness and I clarify the meaning of reductionism about persons. I also argue that a plausible ethical theory is possible even if personites have the same moral status as persons. My arguments draw on Johnston’s earlier debate (...) with Parfit about personal identity and the place of ordinary concerns in a naturalistic world. I also describe an important but metaphysics-free problem that arises from Johnston’s discussion. (shrink)

This paper develops transfinite extensions of transitivity and acyclicity in the context of population ethics. They are used to argue that it is better to add good lives, worse to add bad lives, and equally good to add neutral lives, where a life's value is understood as personal value. These conclusions rule out a number of theories of population ethics, feed into an argument for the repugnant conclusion, and allow us to reduce different-number comparisons to same-number ones. Challenges to these (...) arguments are addressed, including the issue of comparing existence and non-existence in terms of personal value, the possibility of minimal quanta of time and life, and the meaningfulness of measuring closeness between outcomes with different population sizes. An asymmetry is uncovered between transfinite cycles of worseness and betterness, supporting a version of the weak procreative asymmetry. Transfinite transitivity principles are also favourably compared to the better-known principles of continuity. (shrink)

Techniques of text data analysis have been known for many years and commonly used in many areas of life. Text mining enables, among others, the acquisition of information from the text, its filtering, and studying of similarities and relationships. The aim of this paper is to design a method that would make it possible to assess the health quality of dietary supplements, on the basis of text mining techniques. A fictional plant-based product was used in the study, which was compared (...) with other products containing at least one of the tested ingredients registered in the years 2007–2019 in the register of dietary supplements kept by the Chief Sanitary Inspectorate (GIS), which were given either the “consistent” or “to be clarified” status. The obtained results concern the frequency of occurrence of the individual ingredients (St John’s wort/Hypericum, melissa, rose root/Rhodiola) in other products, considering their status in the register. The data thus obtained was subjected to classical statistical analysis in order to find correlations between the presence of a given ingredient and the product status. In view of the obtained results, the text mining analysis may be considered as a helpful tool in the process of internal risk assessment performed by manufacturers of dietary supplements. (shrink)

Anna Mahtani describes a puzzle meant to show that the Ex-Ante Pareto Principle is incomplete as it stands and, since it cannot be completed in a satisfactory manner, decades of debate in welfare economics and ethics are undermined. In this paper, we provide a better solution to the puzzle which saves the Ex-Ante Pareto Principle from this challenge. We also explain how the plausibility of our solution is reinforced by its similarity to a standard solution to an analogous puzzle in (...) quantified epistemic logic. We also show that even if the puzzle were to remain unsolved, its impact on welfare economics and ethics would be limited. (shrink)

As a result of the epidemiological situation in Poland that occurred as a consequence of the SARS-CoV-2 pandemic, all classroom study was suspended in March 2020 and schools were required to deliver online education. There number of teachers who create educational resources for medical e-education, also those including interactive elements, is still insufficient. Teachers’ IT skills must be continuously improved and they have to take part in e-learning course design training programmes, taking into account the characteristics of the teaching process (...) in medical sciences and health studies. The existing examples of effective e-classes, particularly for medical training, are important sources of knowledge on how to build e-learning courses for beginners and an inspiration for others in subsequent implementations. This knowledge is needed immediately, and the time available for acquiring it is shorter than previously, as the epidemic does not allow for full-range training schemes. This paper presents such results, collected from the period from March to June 2020 at the Poznan University of Medical Sciences by teachers who had started working on e-learning resources in 2019 and are successfully implementing these in the educational offer made available to their students as part of various curricula. (shrink)

The aim of this study was to compare medical and social sciences students’ outcomes in terms of self-perceived stress, quality of life, and personality traits. We put particular emphasis on external and internal differences in students of specific fields–medicine, nursing, psychology, and pedagogy. In a survey, 1,783 students from Medical University of Gdańsk and University of Gdańsk participated in our study, of whom 1,223 were included in the final statistical analysis. All of them were evaluated using valid and reliable questionnaires–TIPI-PL, (...) PSS-10, and a one-item scale of quality of life. Stress turned out to have a negative effect on quality of life, regardless of the type of field of study. Moreover, students from different fields varied in terms of personality factors: conscientiousness, agreeableness, openness to experience, and emotional stability. In conclusion, many students regardless of their field suffer from high stress and report low quality of life, which potentially further affects their academic performance and social life. (shrink)

Inspired by Castañeda (1966, 1968), Perry (1979) and Lewis (1979) showed that a specific variety of singular thoughts, thoughts about oneself “as oneself” – de se thoughts, as Lewis called them – raise special issues, and they advanced rival accounts. Their suggestive examples raise the problem of de se thought – to wit, how to characterize it so as to give an accurate account of the data, tracing its relations to singular thoughts in general. After rehearsing the main tenets of (...) two contrasting accounts – a Lewisian one and a Perrian one – in the first section of this paper, in the second I will present a proposal of my own, which is a specific elaboration of the Perrian account. In the first section I will indicate some weaknesses of Perry’s presentation of his view; the proposal I will articulate in the second overcomes them. I will conclude with a brief discussion of reasons for preferring one or another account, in particular regarding the issue of the communication of de se thoughts. (shrink)

В книге говорится о творце, генерирующем творческие акты – непредсказуемые решения and (озарения and ), феномены, которыми обладает только человек-личность. Общественные институты, как и само общество в целом, не могут исключительно своими социальными усилиями генерировать творческий акт. Таким образом, без этого личностного, практически абсолютно автономного, творческого решения общество не может ни обойтись, ни чем-либо его заменить. Используя творческие акты, эти феномены, имманентные только человеку, общество консолидируется и развивается, и, таким образом, человек-творец становится двигателем истории человечества. В этом смысле категория личность (...) имеет не меньшую значимость, чем категория производительные силы или категория общество. Рассматривается концепция природы творчества по Вифляеву, с полным философским обоснованием. (shrink)

This book includes a critical edition, Turkish translation and study of Tasköprüzade's gloss on Jurjani's commentary on Zamakhsharī's al-Kashshaf by Jurjani.

Volume 13 in the Major Conservative and Libertarian thinkers series focuses on F.A. Hayek, The influential member of the Austrian School of Economics.

t. 1. Noosferizm : vvedenie v noosferizm, Noosferizm: dvizhenie, ideologii︠a︡ ili novai︠a︡ nauchno-mirovozzrecheskai︠a︡ sistema? -- t. 2. Noosferizm : Kapitalokratii︠a︡ mify liberizma ... -- t. 3. Noosferizm : Rossii︠a︡ v XXI veke v kontekste ... -- t. 4, kn. 1. Noosferizm : Noosfernoe ili neklassicheskoe chelovekovedeni; kn. 2. Noosfernoe ili neklassicheskoe chelovekovedenie: poisk osnovaniĭ -- t. 5, kn. 1. Noosfernoe ili neklassicheskoe chelovekovedenie: poisk osnovaniĭ; kn. 12. Noosfernoe ili neklassicheskoe chelovekovedenie: poisk osnovaniĭ -- t. 6. kn. 1. Obrazovanie--vysshiĭ imperativ noosfernogo (...) ili ustoĭchivogo razvitii︢a︡ Rossii v XXI veke; kn. 2 Obrazovanie--vysshiĭ imperativ noosfernogo ili ustoĭchivogo razvitii︢a︡ Rossii v XXI veke -- t. 7. Sistemologii︠a︡ obrazovanii︠a︡ i obrazovanievedenie. (shrink)